Projects Investigator Sponsor
Burst Wave Lithotripsy: An Experimental Method to Fragment Kidney Stones

CIMU researchers are investigating a noninvasive method to fragment kidney stones using ultrasound pulses rather than shock waves. Consecutive acoustic cycles accumulate and concentrate energy within the stone. The technique can be 'tuned' to create small fragments, potentially improving the success rate of lithotripsy procedures.

Adam Maxwell
Wayne Kreider
Bryan Cunitz
Oleg Sapozhnikov
Mike Bailey
Center for Industrial and Medical Ultrasound - CIMU

CIMU is a group of scientists, engineers, and technicians dedicated to research across the field of bio-medical ultrasonics with the goal of developing technologies that will be used in a clinic to treat patients.

Mike Bailey
Bryan Cunitz
Barbrina Dunmire
Tom Matula
Flow Cytometry Techniques Advance Microbubble Science

Researchers at the Center for Industrial and Medical Ultrasound (CIMU) are measuring the physical properties of ultrasound contrast agents — tiny gas bubbles several microns in diameter used to increase sonogram imaging efficiency in the body. When injected to the general circulation they can act as probes and beacons within the body, and can carry and deploy chemotherapeutic payloads. CIMU researchers have developed a hybrid instrument that combines an off-the-shelf flow cytometer with an acoustic transducer. The cytometer's laser interrogation counts and measures the bubbles while the acoustic interrogation reveals the bubbles' viscosity and elasticity at megahertz frequencies.

Andrew Brayman
Brian MacConaghy
Tom Matula
Camilo Perez
Justin Reed
Non-invasive Treatment of Abscesses with Ultrasound

Abscesses are walled-off collections of fluid and bacteria within the body. They are common complications of surgery, trauma, and systemic infections. Typical treatment is the surgical placement of a drainage catheter to drain the abscess fluid over several days. Dr. Keith Chan and researchers at APL-UW's Center for Industrial + Medical Ultrasound are exploring how to treat abscesses non-invasively, that is, from outside the body, with high-intensity focused ultrasound (HIFU). This experimental therapy could reduce pain, radiation exposure, antibiotic use, and costs for patients with abscesses. Therapeutic ultrasound could also treat abscesses too small or inaccessible for conventional drainage.

Keith Chan

Tom Matula
Andrew Brayman
Radiation Pressure from Ultrasound Helps Kidney Stones Pass

A commercial ultrasound imager and a focused ultrasound device are combined to visualize and push a kidney stone from the lower pole of the kidney to the uretropelvic junction to facilitate its passing.

Wei Lu
Bryan Cunitz
Peter Kaczkowski
Oleg Sapozhnikov
Mike Bailey
SonoMotion: A Budding Start-up Company

A research team has developed new technologies to treat kidney stone disease with an ultrasound-based system. Embraced by clinicians, their advances are now being taken to the next step: transition the prototype to an approved device that will roll into hospitals and clinics around the world.

Mike Bailey
Larry Crum
Bryan Cunitz
Barbrina Dunmire

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Terahertz Spectroscopy Methods to Assess Burn Injuries

New imaging techniques may improve the accuracy rate of burn diagnosis. The clinical course of treatment is different for burns of differing severity. Terahertz spectroscopy may improve the differentiation of partial-thickness burns that will heal naturally from those that will require surgical intervention.

Hassan Arbab
Twinkling Artifact Targets Kidney Stones for Lithotripsy Treatment

When kidney stones are imaged by clinical ultrasound imagers in color Doppler mode, they display as a rainbow of colors, making them readily apparent and more effectively targeted for treatment by shock waves.

Marla Paun
John Kucewicz
Oleg Sapozhnikov
Mike Bailey
Larry Crum
Ultrasonic Detection and Propulsion of Kidney Stones

An ultrasound-based system assembled from commercial components and customized software control locates kidney stones, applies an acoustic radiative force, and repositions the stones so they are more likely to pass naturally. Watch urologist test the system.

Mike Bailey
Bryan Cunitz
Peter Kaczkowski
John Kucewicz
Oleg Sapozhnikov
Ultrasound Contrast Agents (Microbubbles) in the Microvasculature

High-speed images of oscillating micro-bubbles in small blood vessels are imaged to observe how the bubble oscillations might help induce permeation in the endothelium, allowing drugs to be transported across that barrier.

Tom Matula
Hong Chen
Andrew Brayman
Rusty Starr
UWAMIT

The uWAMIT center is a collaboration among the College of Engineering, Department of Radiology, and APL-UW to use ultrasound as the main modality for imaging and treating diseases in their early stages.

Tom Matula
Joo Ha Hwang
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